Cancer patient from Blackwood is first in Wales to get the genetic treatment – BBC South East Wales

288
2637
Cancer patient from Blackwood is first in Wales to get the genetic treatment – BBC South East Wales

John Davies had his blood cells taken on Monday

Image caption

John Davies had his blood cells taken on Monday

A patient has become the first in Wales to start on a revolutionary new genetic treatment for blood cancer.

CAR-T therapy involves genetically modifying a type of the body’s immune cells in the hope they will then recognise and destroy cancer cells.

John Davies, 71, from Blackwood, will have his blood frozen in Amsterdam, then modified in the United States before being transfused next month.

Despite chemotherapy for several years, John’s lymphoma has not been cured.

This is the first time in Wales the treatment has been offered after the go-ahead for NHS use last year.

The exact cost of the treatment is commercially sensitive but it is believed to be around a third of a million pounds.

In Wales, it is being funded by the Welsh Health Specialised Services Committee through the New Treatment Fund set up by the Welsh Government in 2017.

In England, CAR-T therapy is being funded through the cancer drugs fund.

This form of immunotherapy is a real world example of precision medicine as it has to be developed for each individual patient.

Image caption

John says: “I expect the worst and hope for the best”

Retired civil servant John found out he had non-Hodgkin lymphoma five years ago when he went for a routine check-up.

He had numerous treatments without success before CAR-T therapy became available.

“It’s not automatic – I’m unlucky to need it but I’m lucky enough to be approved by the panel,” he said.

“I’m a bit of a pioneer, I’m doing this so hopefully that it might help those coming behind me – it might not work for me so I expect the worst and hope for the best.”

What will happen to John’s blood?

Parts of the immune system – white blood cells called T-cells – were removed from John’s blood at the University Hospital of Wales in Cardiff on Monday.

Later that afternoon they were sent by courier to Amsterdam, and were frozen in liquid nitrogen before being flown to a laboratory in California.

There, the white blood cells will be genetically reprogrammed so that rather than killing bacteria and viruses, they will seek out and destroy cancer cells.

They are now “chimeric antigen receptor T-cells” – or CAR-T cells.

The cells will then be multiplied before being returned to Cardiff and put back into John in about a month’s time.

John will need to be carefully monitored for a period in hospital for potentially dangerous side effects after being given the modified cells.

We will be following John’s progress over the next few months.

This is a new therapy and very long-term data is still being generated, yet clinical trials have shown 40% of patients had all signs of their otherwise untreatable, terminal lymphoma eliminated from their body 15 months after treatment.

It was approved by the National Institute for Health and Care Excellence for NHS use in 2018 for specific patients for whom other forms of treatment have been unsuccessful.

Cardiff is the ninth site in the UK to offer the treatment – one of 13 specialist centres it is hoped will eventually be able to offer it.

Around 130 patients in the UK have received CAR-T therapy so far in 2019.

Funding has to be approved on case-by-case basis and there will be an evaluation of its cost-effectiveness.

Keith Wilson, clinical director of the South Wales Blood and Marrow Transplant Programme, said: “This is personalised medicine at its best. It’s bespoke, tailored for the patient and unique for that particular patient.

“He has to donate his own cells, these are then tailored to match his own and cancer, and then when we return them to him in about a month’s time, those cells will do what the immune system normally does – fight infection. Except in this case they have been tricked into thinking the cancer is infection.”

John said he was very grateful.

“I’ve paid my tax… for 40 years but I think I’m greatly in arrears now after all the wonderful treatment.”

288 COMMENTS

  1. perfect design thanks The British brothers being questioned, who are believed to be from Jersey, were stopped at Bangkok International Airport as they prepared to leave the country, BBC south-east Asia correspondent Jonathan Head said.

  2. No, I’m not particularly sporty The affordability of energy bills is a contentious issue asprices have risen substantially over past years, partially dueto payments for green energy and social schemes

  3. The manager With more and more people using these types of investments,you may find yourself wondering, “Should I be using target-date funds?”Whether you are two, 10 or 50 years away from retiring, you should answer thesethree questions before adding one to your portfolio.

  4. How many weeks’ holiday a year are there? Paramedics rushed Daniels to Staten Island University South Hospital with a massive head injury, officials said

  5. Who do you work for? Quarterback Geno Smith had fixed the problem on the field, but the timeout was granted as defensive lineman Sheldon Richardson shouted into an official’s ear

  6. I’d like to send this to The committee has suggested three options for replacing section 51(26) to ensure that specific Indigenous laws like native title and heritage protection are preserved and to provide either broad, limited, or no protection on racial discrimination.

  7. Whereabouts are you from? The drive is being led by the Service EmployeesInternational Union (SEIU), whose 2 million members includehealthcare workers, building staff, local and state governmentworkers and public school employees.

  8. In a meeting Rights groups accuse Aliyev, who succeeded his father in2003, of clamping down on dissent and rigging elections, but sayhe has been cushioned from Western criticism because ofAzerbaijan’s role as an oil supplier to Europe and transit routefor U.S

  9. It’s a bad line “With a power lefty who strikes out a lot of guys and a power righty, the lineups just might match up where one day he’s the eighth inning guy and then one day he’s the ninth inning guy a little bit better.”

  10. Could you tell me the number for ? For that matter, there is much speculation that new GM John Hart will take stock of the Braves’ situation, which includes some bad contracts, and retool a bit before the ballclub moves into its new stadium in 2017.

  11. Stolen credit card Mr Stevens has already said that GPs, hospitals, community health services and social services must pool their thinking to provide joined-up care for patients

  12. I love the theatre flight schedules were upended for a second day during the year’s busiest travel period, with 56 flights canceled and 403 delayed on Thursday, according to FlightAware.com

  13. We’d like to offer you the job That’s a growing political liability for Republicans because the nonpartisan Congressional Budget Office estimates that this year, 19 million Americans will receive coverage as a result of the law, including large numbers in GOP-dominated states.

  14. Do you need a work permit? During the procedure, scarred or diseased corneal tissue is removed and replaced with healthy tissue from an organ donor.

  15. Excellent work, Nice Design She said that the high number of callers during 2014 had ‘placed a pressure on staff to find other services for callers as there is a concern around Connect’s ability to provide intensive ongoing support to such a high number of individual callers’.

  16. I’ve only just arrived “The jobless claims numbers continue to point to improvedlabor markets and good prospects ahead, but soft data for thefirst quarter should keep the Fed on hold,” said Michael Jones,chief investment officer at RiverFront Investment Group inRichmond, Virginia

  17. Punk not dead D’Angelo argued that Officer Wilfredo Diaz, who fired the initial rounds after Russell drove the Malibu toward him, could have killed Russell and Williams

  18. What sort of music do you listen to? Grande, who held hands with rapper Big Sean backstage, kicked off the show with a performance of her EDM hit, “Break Free” in a Beyonce-inspired leotard

  19. I quite like cooking It didn’t turn out that way; indeed the 2012 contest became a kind of “base election” where both candidates ran behind what John McCain polled in losing the 2008 race and Obama picked off states from Republican ranks.

  20. I’d like to send this letter by Another feature that really stands out to me is one that allows you to create an eye-catching Facebook cover photo / profile photo combination

  21. I’m happy very good site The bodies of two of the world’s top skiers, Andreas Fransson of Sweden and Canada’s JP Auclair, were found on Tuesday after they were reported missing in an avalanche in the Andes, authorities said.

  22. I saw your advert in the paper Like Sam Smith at the Grammys, when he thanked his ex-boyfriendwho broke his heart for enabling him to write his hits, Rind dedicates the bookto her ex-husband

  23. I don’t know what I want to do after university When the battle to recapture Tikrit began on March 2, the defense and interior ministers were largely bypassed by the Shi’ite militias, referred to as Popular Mobilization Committees, according to accounts by two senior officials and a Western diplomat, all speaking on condition of anonymity.

  24. Could I have an application form? The difference was due mostly to slower growth in enrollment and spending changes included in the health care law, including reductions in federal payments to the private Medicare Advantage plans that offer an alternative to traditional Medicare

  25. On another call Sources told Reuters in May that utilities and thegovernment were in talks about handing responsibility fordismantling the plants to a ‘bad bank’ for nuclear energy tomeet a 2022 deadline set by the government after the Fukushimadisaster in Japan three years ago.

  26. I’m at Liverpool University Designed to “offer a great sense of nostalgia to long-time PlayStation fans, while also providing a fresh experience to those who never picked up the original console,” according to Andrew House, president and Group CEO of Sony Computer Entertainment, Inc, the 20th Anniversary Edition will be available for 49,980 Yen in Japan, $499 in North America, and €499 in Europe

  27. I came here to work “We aim to empower people with education that will improve their lives, the lives of their families, and the communities they live in.”

  28. What’s the last date I can post this to to arrive in time for Christmas? With the weaker rouble pushing up the value of banks’liabilities relative to their assets, analysts at CapitalEconomics calculate that “if the rouble remains at its currentlevel of 45 per dollar, the hit to banks’ balance sheets couldbe around one trillion roubles ($22 billion)”.

  29. I want to make a withdrawal So what does baseball do? As one high-level baseball exec said to me last week: “We need, as an industry, to do away with night getaway games

  30. I really like swimming There’s more to an election than running commercials, however, just as there’s more to winning a war than just using air power

  31. How many more years do you have to go? The Brooklyn Episcopalian minister was arrested for drunk driving Friday after she was caught weaving through the Holland Tunnel with an open bottle of Absolut vodka in the center console of the car, officials said.

  32. Very Good Site Do Dave and Nick still like each other nearly five years on from those chummy scenes in the Downing Street rose garden at the birth of the coalition? That was the question to the pair as they staged what might well be their final public appearance together in Cardiff

  33. Remove card The 27-year-old Serb, limping from two slips on court, breathing heavily and battling a “physical crisis”, overcame a fired-up Andy Murray 7-6(5) 6-7(4) 6-3 6-0 to clinch his fourth Australian title in the past five years.

  34. Could you send me an application form? Cardiff are frustrated that Palace only received a fine of around 25,000 from the Premier League for breaching league regulations, with the London club accused of obtaining the starting XI before their game in April.

  35. I’m on business The trading and mining company’s shares were hit by a slumpin copper prices this year, and its debt is high, diminishingits dealmaking ability and focusing attention instead on thequality of assets that it bought in previous spending sprees.

  36. What do you do for a living? “It is difficult to give an estimation of the quantum ofcapital banks will need to have as it will be on a case by casebasis so we can’t say in advance what it will be,” addedCappiello

  37. I’m in my first year at university The visits had “successfully enhanced identification withthe motherland among some pro-green Taiwanese,” the TaiwanDemocratic Self-Government League, a nominally independentpolitical group that is permitted to operate by the CommunistParty, wrote in its report

  38. Do you like it here? Wang Yi, a member of the China Academy of Sciences and adviser to China’s climate negotiation team, said the country should include an absolute CO2 cap of around 10 billion tonnes for 2020 in its five-year plan covering the 2016-2020 period.

  39. Where do you come from? The plan is to build on an existing set of green policygoals to 2020, which have greatly increased the amount ofrenewable energy such as the sun and wind used across theEuropean Union and cut overall energy use through measures suchas better building insulation and more fuel-efficient vehicles.

  40. How much does the job pay? Encrypting e-mail is effective, but requires that both the sender and recipient of a message use the same specific encryption protocol to maintain privacy

  41. Is there ? “I don’t know if there’s ever a time, the number of years you wait, but obviously he meant a ton to this organization and he meant a ton to us as players and his leadership

  42. I’m from England The technology blogger Robert Scoble said he could not now imagine living a day without the product, and was even photographed wearing it in the shower.

  43. I’m on work experience They were split into three groups – those whose mothers had epilepsy and took anti-epileptic medication, those whose mothers had epilepsy but did not take medication and those whose mothers did not have epilepsy.

  44. Wonderfull great site Their supplied donor was described as having a 160 IQ, a bachelor of science in neuroscience and a master’s degree in artificial intelligence

  45. It’s OK Dollar Tree does not have any outstanding bonds but itsMoody’s rating of Baa3 is under review for downgrade as itsacquisition bid of US$8.5bn supported by committed financing ofUS$9.5bn will take its pro forma debt to 5.6 times Ebitda from3.3 times at the end of 2013.

  46. I’d like a phonecard, please Last week the former head of English education watchdog Ofsted, Sir David Bell, warned that attempts to raise standards in England's schools were being undermined by political interference and short-term demands of party politics.

  47. I enjoy travelling The Obama administration Friday appealed a recent World Trade Organization ruling that would have limited meat-origin labeling, angering Canadian officials who threatened retaliation for what they called violations of international trade rules.

  48. Another year The study found that the combination of stress and high depression greatly increased the participants’ risk of suffering a heart attack or dying

  49. I sing in a choir Among isolation care doctors and nurses, 14 percent said they’d call in sick, and one in four critical care and emergency staff said the same

  50. I hate shopping It became known as UPI when after a merger with the International News Service in 1958, which was founded in 1909 by William Randolph Hearst

  51. Excellent work, Nice Design The Mets considered trade options during the offseason but opted to keep him and planned to use a rotation of Matt Harvey, Wheeler, Jacob deGrom, Bartolo Colon and Jon Niese.

  52. Will I be paid weekly or monthly? Jeter admitted on Wednesday that not only was he guarded with reporters — not exactly the kind of breaking news he wants for his new site — but that he had only survived in New York by being careful with what he said.

  53. One moment, please Firstly, his girlfriend was moving to Toronto to go to business school, and secondly he recognised that it was a much larger and more lucrative marketplace for the website and app design business he had co-founded.

  54. I work for myself In 2002, security voters catapulted the Republicans into a Senate majority,” says Matt Schlapp, chairman of the American Conservative Union and a former White House political adviser to George W

  55. Do you know what extension he’s on? Attorney Serrin Turner said Ulbricht operated the site from beginning to end and was willing to do anything to protect it

  56. Stolen credit card To Minneapolis Fed President Narayana Kocherlakota, policymakers who worry about too-high inflation are caught in a time warp from the 1970s, when price rises were in the double digits and President Gerald Ford was organizing the “Whip Inflation Now” campaign, or WIN for short.

  57. Could I have , please? JAKARTA – As negotiations to resolve an increasingly bitterdispute over Indonesian mining rules teetered on the brink ofcollapse, the chairman of Freeport-McMoRan Inc James “Jim Bob”Moffett flew to Jakarta for last-ditch talks

  58. I’d like to tell you about a change of address Unless they are eligible for asylum or have families or jobs in Europe, they risk expulsion by Italy.

  59. Do you know the number for ? After two British banks – Edinburgh-based Lloyds and RBS – said they would shift their registered head offices to London if Scotland voted to break away, Salmond accused the British government of orchestrating a campaign of fear by corporate lenders.

  60. Enter your PIN Could this be the race that sees these two big beasts lock horns decisively? Or will the parcours be better suited to young guns such as Team Sky’s Ben Swift or NFTO’s Adam Blythe?

  61. I’ll call back later Former British Prime Minister Tony Blair, who also presided over the Good Friday Agreement, said Paisley had been an “uncompromising, even intransigent” opponent, but ultimately knew when to compromise.

  62. I’m sorry, I didn’t catch your name His poetry is fueled by his love of work profoundly connected to the land, which he believes is the heart of the cowboy soul

  63. Withdraw cash In May 2013, the trial judge found that racial profiling had occurred during traffic stops and that drivers were being detained for too long

  64. A law firm Meanwhile, those who used two or three devices were 50% more likely to sleep for less than five hours compared to those who used just one device

  65. I saw your advert in the paper With a legal stand-off emerging between HIQA and the HSE over the findings of the Portlaoise probe, a leading expert has said the hospital’s rate of unexpected infant deaths in recent years is well within current norms

  66. No, I’m not particularly sporty “But both Sky and minorities have the same agenda — which is to create more value from Sky Deutschland.”

  67. How much is a First Class stamp? Morgan Stanley decided to take a nearly $1 billion loss on the project rather than spending more than $1 billion more to finish the project

  68. What qualifications have you got? The survey also found that over 60% of specialist dementia services were provided by private nursing homes, yet the private sector received significantly less funding for the care of older people from the National Treatment and Purchase Fund.

  69. I love this site Mechel’s pessimistic scenario suggests that it can get $2-3billion for these assets, which together with the potential saleof a railroad to its Elga coal mine in Russia’s far east andimproving global market conditions could allow the company torepay $4-5 billion of its debt.

  70. Punk not dead He devotes an engrossing chapter to the machinations behind what is without doubt his most historic accomplishment to date — the legalization of same-sex marriage in New York State

  71. Good crew it’s cool 🙂 Laquan started his fashion career at the tender age of 19, working with esteemed legends in the industry like stylist Elizabeth Sulcer and Andre Leon Talley

  72. I love this site With the outcome too close to call, bankers had advised companies that were due to pull the trigger on a float last week to hold off until the result was known

  73. I’m not working at the moment “Facebook places cookies whenever someone visits a webpage belonging to the facebook.com domain, even if the visitor is not a Facebook user,” states the report

  74. I’d like to pay this cheque in, please The brief, surprise mention of segregated accounts in theminutes suggests that the Fed’s overnight reverse repurchasefacility, a fixed-rate full-allotment tool known as “ON RRP”that has been tested since last year, could again be relegatedin the Fed’s toolbox.

  75. I’d like to speak to someone about a mortgage The study raises important questions, but can’t prove that instant noodles are to blame rather than the overall diets of people who eat lots of them, cautions Alice Lichtenstein, director of the cardiovascular nutrition lab at Tufts University in Boston.

  76. I’m a trainee A working woman in Delhi – and this is something I know from personal experience – is constantly weighing up affordability and safety

  77. I’d like to transfer some money to this account After the initial panic, everyone has shifted into acceptance mode at Ohio State: Braxton Miller will not be available this season after re-injuring his shoulder, meaning this is redshirt freshman J.T

  78. Could you tell me the number for ? “For the building of real rule of law, redressing any misjudged cases, the ones involving wrongly executed innocent people such as Huugjilt in particular, is of milestone importance,” says the paper.

  79. A pension scheme “The public was so disgusted by Booth’s atrocity that most all letters, signatures and documents mentioning him were destroyed immediately after Lincoln’s death, making any that survive 150 years later exceedingly uncommon and worthwhile,” said Don Ackerman, Consignment Director for Historical Americana at Heritage Auctions, which performed the most recent sale.

  80. I enjoy travelling “He just said, ‘Congratulations on great play, but we’re going to go in another direction.’ He kind of started to explain his reasoning, and I wasn’t rude at all or anything, but if you’re not one getting picked ..

  81. What company are you calling from? He added, “Finding a way to continue to reinforce the world’s commitment to bringing North Korea around to sanity seems a pretty compelling objective — which might lead them to deviate from standard practice.”

  82. Whereabouts are you from? “The expression ‘avoiding the Mexicanization’ was utilized by the Pope in a strictly personal and informal email, in response to an Argentine friend very committed to the struggle against drugs, who had used this phrase,” the Vatican said.

  83. Can you hear me OK? Health Secretary Shona Robison said integration was one of the Scottish Government’s most ambitious programmes, and would shift focus from acute care to home-based care as Scotland’s population of older people grows.

  84. I’d like to change some money The bank last month posted a 16 percent drop in third-quarter pretax profit to $1.53 billion from a year ago asimpairments for bad loans almost doubled and regulatory andcompliance costs increased

  85. How many more years do you have to go? NEW YORK (AP) — A plan for a luxury skyscraper with a so-called “poor door” is changing to extend more of a welcome to residents of its cluster of affordable apartments, officials and the developers said Friday.

  86. What’s your number? What he didn’t say was that these same players who are complaining about Mike Woodson are the most likely to complain about Fisher, if the losing continues.

  87. I’m unemployed And other Russian citizens who played a prominent role in the formation of the separatist republics have also now left Ukraine, at least partly it seems under pressure from Moscow

  88. How many days will it take for the cheque to clear? A recent Stanford study suggested that converting to a renewable-powered energy system could yield more than 200,000 jobs in California alone

  89. What sort of music do you like? The New York City Department of Sanitation rolled out 2,100 snow plows, salt spreaders and other equipment to de-ice roads and sidewalks, a spokeswoman said

  90. Yes, I love it! While Israel says it has killed several hundred Hamas militants in the conflict, they have largely been front-line fighters, not the organization’s commanders.

  91. I don’t know what I want to do after university Expressing a similar view, Mr Sisay says Liberia and Sierra Leone have hit “rock-bottom” since the Ebola outbreak – and a concerted effort will have to be made by their governments and foreign donors to ensure they are better-placed to cope with any future crisis.

  92. Could you ask her to call me? He has 12 wins from 15 matches, and is on a seven-match winning streak — the last four coming at the “Miracle in Medinah” in 2012 when Europe came from 10-6 down on the final day to retain the cup.

  93. I work with computers The grand jury is deciding whether to charge officer Darren Wilson in the slaying of 18-year-old Michael Brown in the St

  94. I’d like a phonecard, please While less dedicated fancy dressers may opt for a slutty witch costume, Klum put aside all thoughts of vanity when she dressed as an extremely realistic old lady

  95. Your account’s overdrawn The report added that when it comes to dentistry, the main interests seem to relate to fluoridation and orthodontics and there is little or no political representation about important issues such as the provision of dental services to people with disabilities, and the prevalence and suffering caused by cavities during childhood.

  96. Do you know the number for ? A common thread through this process of discovery is scientific method: the taking of almost infinite pains in the gathering of data followed by careful reasoning and bold leaps of imagination resulting in a new, testable hypothesis

  97. Who’s calling? The committee called for more “advance care planning” for end-of-life by individuals, for improved training and credentialing for clinicians, and for federal and state governments and private sectors to provide incentives to patients and clinicians to discuss issues, values, preferences, and appropriate services and care.

  98. A law firm The national charity, which offers advice, support and education to people with diabetes, is hosting a diabetes management workshop in Dublin next weekend, in an attempt to help people improve their control of the condition.

  99. Could I have , please? German officials, including Finance Minister Wolfgang Schaeuble are not happy, fearing some eurozone governments now will not make essential economic reforms as the pressure will have been taken off them.

  100. this post is fantastic This comes from our ad serving technology and is used to track how many times you have seen a particular ad on our sites, so that you don’t just see one advert but an even spread

  101. Another service? The drugs are believed to havepotential benefits for patients suffering from depression, anxietyand alcohol addiction, but research into these therapeuticproperties previously stalled after they were banned in the UK in1971.

  102. I can’t get a dialling tone The Sidley Austin lawyers did not discover the November orders until 51 days later, in January, after the appeal period had expired

  103. How would you like the money? The idea had foundered primarily because Europe’s demand forgas fell in the global financial crisis, making the project nolonger economically viable for investors, including some majorEuropean energy companies.

  104. A few months The manufacturer has tweaked the popular design with new exterior body panels, to give it greater definition, and a redesigned interior including a new-look instrument panel and dashboard

  105. The United States “He gave Landrieu another bit of help, according to one Democraticsenator, by not issuing a formal alert known as a hotline letting colleaguesknow that she was seeking unanimous consent for a vote,” The Hill reported

  106. One moment, please Mark Spiwak, president of Boeing Satellite Systems International, said he expected demand for GEO satellites to remain steady at about two dozen a year, but he said those satellites would clearly need to have greater processing power and larger bandwidth, given rising demand for global connectivity.

  107. I’d like to send this to Ana was expected to bring heavy surf to south-facing beaches and remained dangerous, whether at tropical storm or hurricane strength, because the uncertainties involved in storm forecasts meant it could still nudge itself closer to the islands, Tanabe added.

  108. How many days will it take for the cheque to clear? “We did this study simply because there wasn’t a lot of data out there already about what are the factors related to sleep-related deaths on sofas,” said Dr

  109. Thanks funny site District Judge Gregory Sleet in Delaware on Monday invalidated four Cubicin patents and ruled that Hospira Inc can launch a generic version of Cubicin as soon as 2016,two years sooner than Wall Street expectations.

  110. Can I take your number? The Confederation of British Industry survey’s total order book balance fell to zero in March, a five-month low, from 10 in February, though it is still well above its long-run average

  111. I came here to work Throughout the history of medicine some doctors have declined to treat infectious patients or fled epidemics, said Michigan’s Markel

  112. Who’s calling? In the third inning of that Friday night home game against the Astros, after Ruben Tejada had drawn a walk, Collins signaled for his pitcher to bunt

  113. i’m fine good work The allegations focus on a contractfor the islands’ public hospital swipe-card billing technologywhen he was in charge of the Health Services Authority.

  114. I have my own business Massad, who took the helm at the agency in June, has oftensaid he would tweak any of the rules if they made life harderfor the original market users, though he must walk a fine lineso as not to be seen as weakening the agency’s oversight.

  115. I’d like to withdraw $100, please Ovechkin’s dynamic play was familiar to Avalanche fans who watched Peter Forsberg score impossible goals throughout his career

  116. Which year are you in? “My mother would be so touched by the tributes and prayers that we have received from around the world,” Melissa Rivers said in a statement Friday

  117. This site is crazy 🙂 Turkey has so far been cool to any international coalition to fight the Islamic State group, but if Western countries are seen publicly arming the Syrian Kurds, it would likely destroy any hopes of cajoling the Turkish government into co-operating.

  118. Do you know the address? More than 40 heads of state came together in Paris to denounce a wave of terrorism that defiled the City of Light last week — yet there was one glaring exception: The U.S

  119. I love this site 22 when the ECB meets wecould be setting ourselves up for sell the rumor, buy the fact.Maybe when the ECB announces what they do, perhaps there is onemore push down in the euro and then people buy it back to takeprofits (on those short positions,)” he said.

  120. My battery’s about to run out As recently as March 2013 the permit to bring in the whales seemed to be getting the green light, said Daniel Diffley, an attorney for the aquarium

  121. Do you have any exams coming up? “Whilst my review of the whole business continues, three immediate priorities are clear: to recover our competitiveness in the UK, to protect and strengthen our balance sheet and to begin the long journey back to building trust and tran sparency into our business and brand.”

  122. Have you got any experience? The ECB is carrying out the checks of how the biggest euro zone banks have valued their assets, and whether they have enough capital to weather another economic crash, before taking over as their supervisor

  123. Can I take your number? SurfStitch’s current owners, its founding directors and fundmanagers Perpetual Ltd, Paradice Investment Managementand Ausbil Investment Management Ltd, all kept large stakes inthe company after listing, a source working on the sale toldReuters.($1 = 1.2162 Australian dollars) (Reporting by Byron Kaye; Editing by Stephen Coates)

  124. Have you got any qualifications? Iran, once OPEC’s second-largest exporter, is expected totry to sell more oil to Asian consumers such as China and Indiabefore a final nuclear deal due in June, which Tehran hopes willlift Western sanctions that have curbed its oil exports by morethan half and crippled its economy.

  125. A Second Class stamp Faced with finance ministers of the euro zone who had, in many cases, swallowed great draughts of austerity and struggled to meet the conditions for loans and bailouts, Greece had backed down substantially.

  126. Jonny was here “I guess you can make a case that both of those guys have had their share of bumps in the road along the way, so there’s always the chance that the added stress of closing could mess with their confidence

  127. We work together “Together, we are focusing on identifying, investigating, engaging, and ultimately removing perpetrators of violence from our streets.”

  128. Get a job But AstraZeneca's recent activity–buying Almirall for $2.1 billion and further talking up its much-hyped oncology pipeline–doesn't suggest the company is looking to be acquired any time soon, and analysts say any resumption of buyout talk is likely to come in November, when Pfizer will be free to make another public bid on its former target.

  129. A packet of envelopes Regardless of whether you believe in the value of active asset management, a new study of the global experience shows that the growth of index funds tends to make active funds more truly active and better performers.

  130. I’m from England The researchers determined that the latter is more likely the case, as the limpet’s blue stripes resemble the patterning of poisonous marine snails that also happen to inhabit similar kelp beds.

  131. Where do you study? Because it is only transmitted by direct contact, theEbola transmission rate – the average number of cases generated by a single case- is much lower

  132. A book of First Class stamps To preserve the event’s integrity, the health department does not advertise the ball to the public and instead allows news of it to spread through word of mouth

  133. Have you got a current driving licence? She added the termination of interest-rate hedges and letters of credit on existing variable-rate bonds could be triggered, costing Chicago hundreds of millions of dollars.

  134. Your account’s overdrawn However, interviews with numerous space experts from industry, government and elsewhere reveal a growing consensus that Boeing is likely to emerge as the big winner to develop and operate the replacement for the space-shuttle fleet, which was retired in 2011.

  135. I’ve come to collect a parcel Kurzweil started working on so-called “reading machines” inthe early 1970s after chatting on a plane with a blind personwho voiced frustrations with the lack of optical-recognitiontechnology on the market.

  136. I’ll put him on Israel’s Antiquities Authority said on Sunday the ceramic vessels, crafted in an Egyptian method that differed from local pottery-making at the time, would have held a thick, partially baked barley and water mixture left to ferment in the sun.

  137. I work for myself Republicans are highlighting Detroit, which emerged in December from a 17-month bankruptcy, as an example of the perils of big government and a possible testing ground for conservative ideas like tax reductions.

  138. Will I get travelling expenses? She has had lots of visitors – first, her sister's son came and then the rest of her family and she has met her great grand nephews and nieces too

  139. It’s OK Helped by the spread of TV and the Internet, Afghanistan has witnessed a rapid rise in interest in sports under the government that succeeded the hardline Islamists, who had banned television and many sports and martial arts.

  140. Do you know what extension he’s on? Callahan skated from behind the net and snapped a shot past Panthers goalie Roberto Luongo from the left circle with 2:28 left on the clock.

  141. A financial advisor than South Florida because they don’t tolerate colder weather, but a hybrid might be able to thrive in a greater range than either species alone.

  142. Pleased to meet you His horses have earned more than $40 million at the races, and he’s encountered the emotional ups and downs of the sport during a short period:

  143. Sorry, I ran out of credit Kurdish and Shiite militias are fighting back, less for the sake of a unified Iraq as for their own national and sectarian goals

  144. An estate agents Under the agreement, the Government has pledged to increase its investment in providing GP services to children under the age of six to €67 million – an 81% increase on the €37 million originally identified by Government, according to the IMO.

  145. Best Site good looking Alibaba accounts for about 80 percent of all online retailsales in China, where rising Internet usage and an expandingmiddle class helped the company generate gross merchandisevolume of $296 billion in the 12 months ended June 30

  146. I quite like cooking Almost immediately, the world united around the hashtag #jesuischarlie as a symbol of that key democratic value: free speech

  147. Another year The advisory council includes eight representatives fromoutside Google, including a former German justice minister andtwo academics, as well as Google’s general counsel DavidDrummond and chairman Eric Schmidt.

  148. I like watching football “You can do almost everything online these days, but unlisted equities is one of the last areas that has been overly mystified and kept out of reach of the ordinary investor,” she says.

  149. I’d like to cancel this standing order Donald Newbury, 52, became the third member of the group known as the “Texas 7” executed for the fatal shooting of 29-year-old Aubrey Hawkins, an Irving officer who interrupted the fugitives’ robbery of a sporting goods store on Christmas Eve in 2000.

  150. Do you like it here? Mr Dutton said “false and irresponsible claims being circulated by some advocates” were undermining the work of staff at the centre

  151. I’m in a band The cops I speak with have as little enthusiasm for policing these low-level, high-friction offenses as they did in annually detaining hundreds of thousands of completely innocent men of color under the prior city administration’s now-discredited stop-question-frisk program

  152. Withdraw cash This has always been the shape of charity in relation to welfare, and it’s strange that someone so fixated on the past as Ernst would try to change that now.

  153. What do you like doing in your spare time? While it depends on the cognitive ability of the patient, offering to talk to a family member is always good practice

  154. I’d like to pay this in, please On the day Berman was killed, cops got an anonymous letter warning them there was a “cadaver” at her home

  155. How much does the job pay? The limpet shells represent the first-ever discovered use of mineralized structural components to produce optical displays

  156. I need to charge up my phone The Premier League club, 20 times English champions, claim to have 659 million followers around the globe, making the United name attractive to major brands like Chevrolet cars and sportswear group Adidas.

  157. Best Site good looking Professor Gillian Leng, of NICE, said: “We must stop the revolving door scenario where people are made ill by living in a cold home, they go into hospital for treatment, but are then discharged back to the cold home which continues to damage their health.”

  158. Where’s the nearest cash machine? But activists say much more needs to be done, including better educating youths and adding basic infrastructure, such as street lights and public bathrooms.

  159. Which team do you support? Last week, WHO estimated there could be another 20,000 cases before the Ebola outbreak is stopped, a figure Brown described as unfortunate but realistic.

  160. I’d like to change some money But Dr Vautrey warned that some of the damage had already been done, as many supposedly ‘high risk’ practices were highlighted via local media outlets as ‘failing’ or being among the worst in their area.

  161. I’d like to take the job “The people who govern us need to make decisions, even painful ones, that bring us to growth,” Giorgio Squinzi, the head of employers’ confederation Confindustria, said at a conference in the seaside town of Rimini.

  162. I don’t like pubs Telecompaper is a well respected, independent research and publishing company focussed on the telecommunications industry.

  163. Jonny was here Greece condemned the “unprovoked and cowardly” attack thatkilled one Greek and one Romanian crew member and wounded twoothers and said it had contacted the U.N

  164. I’d like to speak to someone about a mortgage And as I suggested originally worth a few brownie points in the never ending search for new customers.

  165. I’m at Liverpool University Coats, 35, was paralyzed in a car crash as a teenager and has been a medical marijuana patient since 2009, when he discovered that pot helped calm violent muscle spasms

  166. Special Delivery On her third day at a new school, Miranda Larkin had to go to class in red sweatpants and a hideous, oversized neon yellow T-shirt with “DRESS CODE VIOLATION” emblazoned across the chest and down the leg — an ensemble no high-school kid would voluntarily be caught dead in

  167. Could I make an appointment to see ? iPhone 5, 5s and 5c can use Apple Pay in retail stores only when they have their iPhone paired with an Apple Watch

  168. I have my own business Boko Haram is holding a large swath of northeast Nigeria and declared it is recreating an ancient Islamic caliphate that included parts of Cameroon, Chad and Niger.

  169. I’m sorry, she’s And while it harms individual children the most, it also tears at the fabric of society – undermining stability and progress

  170. I’m at Liverpool University Ukraine’s crisis began when its Moscow-supported leader backed out of an economic agreement with the European Union last year and sparked the protests that would lead to his ouster

  171. Could you give me some smaller notes? They also care for some of the most vulnerable and disadvantaged members of the public, such as those with intellectual disabilities, older people and young people in the care of the HSE.

  172. I’ve got a very weak signal “Journalists who strayed from Hamas’s strict line and reported on rocket fire at Israel, were threatened, and in extreme cases, expelled from Gaza, but none of them ended their lives like James Foley,” Tibon said.

  173. I don’t like pubs The startling conclusion reached by Dr Watson and others is that the planets formed further away, and then migrated in to where we see them today

  174. I’ve just graduated Wang Jun, senior economist at China Centre for InternationalEconomic Exchanges, a Beijing-based think tank, believes thatthe central bank is more likely to cut the reserve requirementratio (RRR) for all of the country’s banks to encourage morelending and support growth.

  175. I support Manchester United The supermodel flaunted her incredible bikini body before enduring the dreaded challenge in a gorgeous gold and black tropical print bikini by Huit, making us put our palms together for her on-trend swimwear style.

  176. I support Manchester United People using the app have the option to complete simple surveys to establish their level of functionality and keep track of their ‘score’ over time as they exercise and improve their flexibility and strength.

  177. We’ve got a joint account Schools that may otherwise be reach schoolscan turn into toss-upsor safety schools if their programs match your interests and strengths.

  178. What do you like doing in your spare time? The owners of the Richmond, California eatery dropped the ads only a few months later, unsatisfied with the results.

  179. I’m originally from Dublin but now live in Edinburgh Luthar studies, to dismiss this hyper-education as a frivolous, albeit painful, form of conspicuous consumption, like cosmetic surgery or flashy cars

  180. Could you ask her to call me? The “news” published today must surely have been one of the first lines of enquiry after the scandal broke: the chances that no-one on the council or in the police was involved in exploiting these children would surely have seemed far too small to ignore the possibility.

  181. Why did you come to ? “The New Year is a time when many of us reflect on how we want our lives to be different, especially our health and our waistlines

  182. Which university are you at? The Ahmed Kathrada Foundation disagreed with him and said: “We consider these attacks to be xenophobic and condemn them as such

  183. I’m self-employed Creating separate rankings forMBA and non-MBA programswill allow potential students to compare themmore fairlyand more effectively.

  184. I can’t get through at the moment Thanks to oil revenues, the desert nation of seven emirates has been on an art-investing binge for three decades that has, for those with deep pockets, made it the region’s prime fine art market.

  185. I work for a publishers When left to your own devices at home, some workers feel the need to deal with mundane domestic chores, or less obliged to work as hard as they would if they felt their boss breathing down their neck.

  186. Good crew it’s cool 🙂 DAVOS, Switzerland – Central banks have done their best to rescue the world economy by printing money and politicians must now act fast to enact structural reforms and pro-investment policies to boost growth, central bankers said on Saturday.

  187. I’ve come to collect a parcel Miller then was recalled only due to Chris Kreider’s unexpected scratch following a death in his family, but fast-forward to Wednesday night’s win in Washington — Miller sat at his locker postgame wearing the Broadway Hat, measuredly speaking about his physical and steady game, having played in 17 straight games and 39 of the last 44.

  188. I’d like to take the job Diagnosis is nothing without support, and to make a real difference in dementia care we need a revolution in what happens after a diagnosis is made.

  189. Best Site Good Work North Korea, already under international sanctions for its nuclear and missile programs, has been on a diplomatic campaign to counter charges by a U.N

  190. I never went to university Stock offerings in Brazil are having theirworst year in more than a decade in yet another sign of erodinginvestor confidence in the nation’s economy.

  191. What’s the current interest rate for personal loans? It's worth remembering, our business editor Kamal Ahmed says, that the head of the GCA was only recently given powers to fine, after the BBC's Panorama programme revealed she had applied for such powers more than a year ago.

  192. Will I have to work shifts? As an ultra-orthodox Jew he says that he believes that what has happened to her must have occurred for a good reason, “But even now I sit next to her and cry,” he says.

  193. I’ll put her on Saturday’s attacks were carried out over a four-hour window, in several locations including a fish market and a bus station, Maiduguri’s police commissioner said.

  194. Could I have a statement, please? Outgoing President Hamid Karzai refused to sign the status of forces agreements and NATO diplomats say that they will have decide on a complete withdrawal within a month unless a new president is installed by then and signs the documents.

  195. I stay at home and look after the children However, when the researchers included other risk factors, such as lifestyle, home environment and genetics, this increased risk of asthma disappeared.

  196. How do I get an outside line? In an unforgiving economy where every dollar counts, the University’s cost of attendance is the exception to the sticker-shock tuition prevalent today

  197. On another call give him a cave wall and a dab of mineral pigment and he could knock out a bison which burst with more power than any picture of a bison you’ve ever seen.

  198. I’ve got a full-time job “It would be a powerful message for the iconic center of our city and the political heart of our country to become smoke free.”

  199. I really like swimming These challenges are not only practical in terms of how we go about living our day-to-day lives, but they are also psychological as we mentally adjust from a sighted to a partially or even non-sighted world,” he said.

  200. A company car 8 of last year, school officials say it is important for parents and guardians of graduating seniors to file the FAFSA forms quickly

  201. Who would I report to? Quvenzhane Wallis, 11, who two years ago became the youngest person to win a Best Actress Oscar nomination, plays the foster kid living a hard-knock life in the multiethnic version of the Tony-winning 1977 Broadway musical that opens in U.S

  202. I’ve just started at In her final entry, she reflects on how distant Christmas feels in Sierra Leone in the wake of a government ban on any public gatherings

  203. In a meeting In contrast, Federal Reserve Chair Janet Yellen on Fridaygave a nod to the concerns of some Fed officials about thesustained level of monetary policy stimulus, even as shestressed the need to move cautiously on raising rates.

  204. real beauty page If the Giants, who have lost four in a row by a combined 74 points to the Eagles, Cowboys, Colts and Seahawks, don’t show some life and get blown out again, then get swept by the Cowboys next week for the second year in a row, then it’s very hard to envision how Tom Coughlin is going to get another shot at this next year after he will have missed the playoffs five of the last six seasons.

  205. An envelope All were regularly asked about general health and diet, including their consumption of fried foods, such as fried chicken, fried fish and French fries.

  206. Is this a temporary or permanent position? Under the direction of Olivier Rousteing, the Paris-based fashion house creates intricately embroidered pieces with expert tailoring

  207. I’ve got a very weak signal The increasing pro-change sentiment has mostly benefited presidential candidate Mauricio Macri, the mayor of Buenos Aires.

  208. I need to charge up my phone What are Facebook’s plans in China?” asked the forum facilitator and Facebook employee Wei Xiaoliang, to laughter and applause from the audience.

  209. Lost credit card Many Russian companies have been hit by a downturn in theeconomy, suffering from weak oil prices and Western sanctionsover the Ukraine crisis, but exporters are enjoying the 50percent drop in the rouble since the beginning of last year.

  210. How do you do? The nonpartisan agency said the deficit for the fiscal year, which ends in September, will be $468 billion, down a tick from last year’s $483 billion mark

  211. How long are you planning to stay here? Much of the 40 million of taxpayers’ money spent on planning for the now abandoned children’s hospital at the Mater site in Dublin may have been wasted, the latest financial statements of the National Paediatric Hospital Development Board have indicated.

  212. History Having hunted down Adam Scott on the final day at Royal Sydney last year to lift the Stonehaven Cup, McIlroy knows he needs to be patient and is convinced there is a low score out on the course for him.

  213. What’s the interest rate on this account? British media quoted a palacesource as saying the monarch was concerned and had asked fordaily updates on the situation.

  214. Could you transfer $1000 from my current account to my deposit account? “Physical activity lowers many heart disease risk factors, which in turn lowers the risk of developing heart failure as well as other heart diseases…Making it easier and safer to walk, bicycle or take the stairs could make a big difference

  215. Which year are you in? “The UK is ahead of its major European neighbours when it comes to broadband and we need to stay ahead as customer demands evolve,” said Mr Patterson

  216. I never went to university The app was developed in conjunction with the National Adult Literacy Agency (NALA) and University College Cork’s Department of Computer Science and School of Nursing and Midwifery, and was funded by the CUH Charity.

  217. What’s your number? It noted that meningitis B leads to death in around 10% of cases and to long-term side effects in a further 36% of cases.

  218. It’s OK If it’s a girl, he’ll be her biggest supporter and confident (sic) and if it’s a boy, I know they’ll be the best of friends, always getting into adventures together.”

  219. I work with computers Iain Duncan Smith’s plan for the “universal credit” benefit payment has been derailed – he insists temporarily, others say permanently – by the inability to find a computer system that is capable of implementing it.

  220. I live here Home runs? Well, maybe Jeter hit “only” 260 of them, 255 as a shortstop (which is fifth behind Ripken, A*Rod, Ernie Banks and Miguel Tejada all-time for shortstops)

  221. We went to university together “Grave, horrific human rights violations are being committed daily by ISIL and associated armed groups,” Pillay said

  222. I’ve just graduated Iraqi Foreign Minister Hoshiyar Zebari urged the world to back his country against Islamic State, which he described as a threat to the world, not just to the minority ethnic groups whose members it has killed in Iraq.

  223. I’d like to send this to ** Swedish Match AB and Skandinavisk Holding, theowners of Scandinavian Tobacco Group (STG), are in talks withprivate equity firms about a possible sale of the cigar maker,two sources familiar with the matter said.

  224. A book of First Class stamps Italian post office Poste Italiane is ready to go publicthis year, its Chief Executive Francesco Caio told daily Il Sole24 Ore on Friday

  225. I’d like to cancel this standing order Some legal observers say Tsarnaev’s lawyers — facing powerful evidence against him — will probably focus their energies on the penalty phase, when they could present mitigating evidence to spare his life

LEAVE A REPLY

Please enter your comment!
Please enter your name here